Local Therapeutics for the Treatment of Oligo Metastatic Prostate Cancer.

Purpose Of Review: Metastatic prostate cancer remains universally lethal. Although de-novo metastatic prostate cancer was historically managed with systemic therapy alone, local therapies are increasingly utilized in the early treatment of the disease, particularly in patients with oligometastatic prostate cancer (OMPC). OMPC represents an intermediate stage between clinically localized and widespread metastatic disease.

DNA Packaging and Genomics of the 9NA-Like Phages.

We present the genome sequences of tailed phages Sasha, Sergei, and Solent. These phages, along with phages 9NA, FSL_SP-062, and FSL_SP-069 and the more distantly related phage PmiS-Isfahan, have similarly sized genomes of between 52 and 57 kbp in length that are largely syntenic. Their genomes also show substantial genome mosaicism relative to one another, which is common within tailed phage clusters.