Plasma protein corona modulates the vascular wall interaction of drug carriers in a material and donor specific manner.

The nanoscale plasma protein interaction with intravenously injected particulate carrier systems is known to modulate their organ distribution and clearance from the bloodstream. However, the role of this plasma protein interaction in prescribing the adhesion of carriers to the vascular wall remains relatively unknown. Here, we show that the adhesion of vascular-targeted poly(lactide-co-glycolic-acid) (PLGA) spheres to endothelial cells is significantly inhibited in human blood flow, with up to 90% reduction in adhesion observed relative to adhesion in simple buffer flow, depending on the particle size and the magnitude and pattern of blood flow.

One-step fabrication of agent-loaded biodegradable microspheroids for drug delivery and imaging applications.

Non-spherical particles may offer advantages over conventional spherical systems for drug delivery applications. This work describes the fabrication of agent-loaded poly(lactic-co-glycolic acid) (PLGA) spheroids via the emulsion solvent evaporation (ESE) method. The versatility of this technique for loading a variety of therapeutics is demonstrated via loading of paclitaxel, bovine serum albumin, and cadmium sulfide nanoparticles into PLGA spheroids.

Design of nanovectors for therapy and imaging of cardiovascular diseases.

Cardiovascular diseases are widely prevalent in western societies, and their associated costs number in the billions of dollars and affect millions of patients each year. Nanovectors targeted to tissues involved in cardiovascular diseases offer great opportunities to improve cardiovascular treatment through their imaging and drug delivery capabilities. Vascular-targeted imaging particles may permit the early identification of atherosclerosis, discriminate between stable and vulnerable atherosclerotic plaques, or guide surgeons as they work on fragile vasculature.

Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery.

Vascular-targeted drug delivery systems could provide more efficient and effective pharmaceutical interventions for treating a variety of diseases including cardiovascular, pulmonary, inflammatory, and malignant disorders. However, several factors must be taken into account when designing these systems. The diverse blood hemodynamics and rheology, and the natural clearance process that tend to decrease the circulation time of foreign particles all lessen the probability of successful carrier interaction with the vascular wall.

Dynamic and cellular interactions of nanoparticles in vascular-targeted drug delivery (review).

Vascular-targeted drug delivery systems could provide more efficient and effective pharmaceutical interventions for treating a variety of diseases including cardiovascular, pulmonary, inflammatory, and malignant disorders. However, several factors must be taken into account when designing these systems. The diverse blood hemodynamics and rheology, and the natural clearance process that tend to decrease the circulation time of foreign particles all lessen the probability of successful carrier interaction with the vascular wall.

Fabrication of biodegradable spheroidal microparticles for drug delivery applications.

Particle shape, in addition to size, is becoming increasingly recognized as important in the design of drug carriers for in vivo use. However, few methods exist for fabricating non-spherical particles from biodegradable polymers. This work describes for the first time the fabrication of biodegradable spheroidal microparticles using the simple oil-in-water emulsion solvent evaporation technique (O/W ESE).