Publications by authors named "Michael J Hertaeg"
Article Synopsis
- Embryonic morphogenesis involves significant tissue deformations to form functional organs, similar to how adult tissues endure mechanical stresses.
- Cells must withstand these stresses and move collectively, responding to both internal cellular activities and external forces from surrounding tissues.
- This study uses a 2D active vertex model to explore how external and internal mechanical influences affect tissue properties, unveiling complex behaviors like yielding and shear thickening, which offer insights into tissue mechanics.
Identification of specific antibodies in patient plasma is an essential part of many diagnostic procedures and is critical for safe blood transfusion. Current techniques require laboratory infrastructure and long turnaround times which limits access to those nearby tertiary healthcare providers. Addressing this challenge, a novel and rapid paper-based antibody test is reported.
View Article and Find Full Text PDFPatterns in dried droplets are commonly observed as rings left after spills of dirty water or coffee have evaporated. Patterns are also seen in dried blood droplets and the patterns have been shown to differ from patients afflicted with different medical conditions. This has been proposed as the basis for a new generation of low-cost blood diagnostics.
View Article and Find Full Text PDFArticle Synopsis
- Pattern formation in drying droplets, especially the ring distribution known as a "coffee ring," is often seen in colloidal systems and can be problematic for manufacturing.
- This study introduces a predictive model that determines when this coffee ring effect will occur in systems with hard spherical particles.
- Findings suggest that a coffee ring develops at low contact angles, with the specific angle depending on the initial concentration of the particle suspension, and the model's predictions align with experimental results using latex suspensions.
Paper-based diagnostics are leading the field of low-cost, point of care analytical techniques. However, large scale testing facilities such as hospitals are still primarily using the gel column agglutination technique. This is because paper-based systems are single use tests that are generally more time consuming and less automatable than traditional methods.
View Article and Find Full Text PDFIn this study, we analyze stain growth kinetics from droplets of biological fluids such as blood, plasma, and protein solutions on paper both experimentally and numerically. The primary difference of biological fluids from a simple fluid is a significant wetting/dewetting hysteresis in paper. This becomes important in later stages of droplet wicking, after the droplet has been completely absorbed into paper.
View Article and Find Full Text PDFHypothesis: The rate of stain growth of a sessile droplet deposited on paper has been previously studied (Kissa, 1981; Danino and Marmur, 1994; Kawase et al., 1986; Borhan and Rungta, 1993) but is not fully understood. In particular, the mechanism by which the abrupt decrease in growth rate occurs is unknown.
View Article and Find Full Text PDFEffect of protein adsorption on the radial wicking of blood droplets in paper.
J Colloid Interface Sci
October 2018
Hypotheses: (1) The equilibrium size and characteristics of a radially wicked fluid on porous material such as paper is expected to be dependent on the fluid properties and therefore could serve as a diagnostic tool. (2) The change in wicked stain size between biological fluids is dependent on a change in solid-liquid surface interfacial energy due to protein adsorption.
Experiments: Sessile droplets of increasing volume of blood, its components, and model fluids were deposited onto paper and the equilibrium stain size after coming to a halt was recorded.