Publications by authors named "Michael J Dubec"
Article Synopsis
- Hypoxia contributes to treatment resistance in solid tumors, and this study investigated whether oxygen-enhanced MRI (OE-MRI) can reliably measure changes in hypoxic volume in patients with HPV-related oropharyngeal cancer during radiotherapy.
- 27 patients underwent imaging before and during treatment, showing that hypoxic volume decreased significantly at two and four weeks into therapy, with notable variations in treatment response across different lesions.
- Results indicate that significant modifications in tumor hypoxia can occur early in treatment, with half of the patients experiencing differing hypoxic changes in primary versus nodal tumors, which could influence patient management and treatment strategies.
Objectives: To measure dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) biomarker repeatability in patients with non-small cell lung cancer (NSCLC). To use these statistics to identify which individual target lesions show early biological response.
Materials And Methods: A single-centre, prospective DCE-MRI study was performed between September 2015 and April 2017.
Background And Purpose: Tumour hypoxia is prognostic in head and neck cancer (HNC), associated with poor loco-regional control, poor survival and treatment resistance. The advent of hybrid MRI - radiotherapy linear accelerator or 'MR Linac' systems - could permit imaging for treatment adaptation based on hypoxic status. We sought to develop oxygen-enhanced MRI (OE-MRI) in HNC and translate the technique onto an MR Linac system.
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