Publications by authors named "Michael J Caiola"
Pulsed electric field (PEF) cardiac ablation has been recently proposed as a technique to treat drug resistant atrial fibrillation by inducing cell death through irreversible electroporation (IRE). Improper PEF dosing can result in thermal damage or reversible electroporation. The lack of comprehensive and systematic studies to select PEF parameters for safe and effective IRE cardiac treatments hinders device development and regulatory decision-making.
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- Optogenetics has transformed neuroscience research in small animals, but its effectiveness in non-human primates (NHPs) has shown mixed results.
- * A centralized database has been created to help researchers track both successful and unsuccessful optogenetic experiments in primates, with contributions from 45 laboratories worldwide.
- * The database, available on the Open Science Framework, aims to enhance research by sharing over 1,000 injection experiments and offers insights to improve optogenetic methods in NHPs.*
Advances in optogenetic and chemogenetic methods to study brain circuits in non-human primates.
J Neural Transm (Vienna)
March 2018
Over the last 10 years, the use of opto- and chemogenetics to modulate neuronal activity in research applications has increased exponentially. Both techniques involve the genetic delivery of artificial proteins (opsins or engineered receptors) that are expressed on a selective population of neurons. The firing of these neurons can then be manipulated using light sources (for opsins) or by systemic administration of exogenous compounds (for chemogenetic receptors).
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