Control of the Iron State in Pharmaceuticals Used for Treatment and Prevention of Iron Deficiency Using Mössbauer Spectroscopy.

Various iron-containing medicaments, vitamins and dietary supplements are used or developed for treatment and prevention of the iron deficiency anemia which is very dangerous for human and may cause various disorders. From the other hand, blood losses, iron poor diet, microelements (co-factors) deficiency, metabolic failures, absorption problems, etc. can change the iron status and affect the health.

Analysis of the iron states in iron-containing pharmaceutical products using Mössbauer spectroscopy.

Iron-containing pharmaceuticals, namely: (i) PreNatal with ferrous fumarate, (ii) Tardyferon® with ferrous sulfate, (iii) Fenules with water free ferrous sulfate, (iv) Iron Complex with iron glycinate, citrate, (v) Gentle Iron, (vi) Hema-Plex® and (vii) Iron Bisglycinate with iron (ferrous) bisglycinate chelate (iron compounds are given as declared by the manufactures) were studied by Fe Mössbauer spectroscopy with X-ray diffraction and magnetization measurements for analysis of the iron state. The obtained results demonstrate that the iron compound announced by the manufacturer in each pharmaceutical is not homogeneous and exists as some modifications of this compound or results of its transformation/oxidation probably due to its instability. The presence of ferrous and ferric compounds is observed, and the relative ferric iron fractions are roughly determined for each pharmaceutical product.

Mössbauer Spectroscopy with a High Velocity Resolution in the Studies of Nanomaterials.

The present review describes our long experience in the application of Mössbauer spectroscopy with a high velocity resolution (a high discretization of the velocity reference signal) in the studies of various nanosized and nanostructured iron-containing materials. The results reviewed discuss investigations of: (I) nanosized iron cores in: (i) extracted ferritin, (ii) ferritin in liver and spleen tissues in normal and pathological cases, (iii) ferritin in bacteria, (iv) pharmaceutical ferritin analogues; (II) nanoparticles developed for magnetic fluids for medical purposes; (III) nanoparticles and nanostructured FINEMET alloys developed for technical purposes. The results obtained demonstrate that the high velocity resolution Mössbauer spectroscopy permits to excavate more information and to extract more spectral components in the complex Mössbauer spectra with overlapped components, in comparison with those obtained by using conventional Mössbauer spectroscopy.

Change in Magnetic Anisotropy at the Surface and in the Bulk of FINEMET Induced by Swift Heavy Ion Irradiation.

Fe transmission and conversion electron Mössbauer spectroscopy as well as XRD were used to study the effect of swift heavy ion irradiation on stress-annealed FINEMET samples with a composition of FeSiNbBCu. The XRD of the samples indicated changes neither in the crystal structure nor in the texture of irradiated ribbons as compared to those of non-irradiated ones. However, changes in the magnetic anisotropy both in the bulk as well as at the surface of the FINEMET alloy ribbons irradiated by 160 MeV Xe ions with a fluence of 10 ion cm were revealed via the decrease in relative areas of the second and fifth lines of the magnetic sextets in the corresponding Mössbauer spectra.