Publications by authors named "Michael Holton"

This paper summarizes historical asbestos exposure data collected during the handling of short-fiber chrysotile asbestos that was used as an additive to drilling fluid in oil and gas exploration. A total of 1171 industrial hygiene (IH) personal and area air samples were collected and analyzed from more than 20 drilling rigs between 1972 and 1985. The dataset consists of 1097 short-term samples (<240 min) with more than 80% having sample durations less than 30 min.

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We appreciate the opportunity to respond to the comments of the letter writer. The writer states in his Letter to the Editor that the findings in our publication are not interpretable and/or cannot be generalized due to the lack of understanding of the source mine and bulk content of the cosmetic talc used in the facial makeups. In brief, we performed an exposure simulation study using established industrial hygiene methods, planned and conducted by Certified Industrial Hygienists (CIHs), to assess asbestos exposures during the use of facial makeups that were found to contain very low levels of asbestos below the conventional detection limits of X-ray diffraction and polarized light microscopy.

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There has been renewed interest in the safety of cosmetics that may contain asbestos or other elongate mineral particles at very low levels as a naturally occurring contaminant. The authors evaluated asbestos exposure during the application of facial makeups in a constructed chamber simulating a bathroom space. The facial makeups tested included products previously found to have very low or "trace" asbestos content by governmental and commercial laboratories using a variety of bulk analysis methods.

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Article Synopsis
  • - The study investigates a new dispersible tablet form of Dolutegravir (DTG) for treating HIV-1 in pediatric patients, comparing its pharmacokinetics to an earlier granule formulation using healthy adults.
  • - Participants received the drug in different forms, with key measures focused on how much of the drug was absorbed into the system and how well it was tolerated.
  • - Results indicated that the dispersible tablet had similar drug exposure as the granules, was not impacted by water mineral content, and had mild side effects, suggesting it's a promising formulation for future use in children.
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