Hemocompatible Surfaces Through Surface-attached Hydrogel Coatings and their Functional Stability in a Medical Environment.

Blood compatible materials are a well-researched scientific field as such materials are required in a wide range of applications, for example, in heart-lung machines or ventricular assist devices. Surfaces coated with certain surface-bound neutral, water-swellable polymer networks have the ability to repel cells such as platelets and exhibit a significantly improved hemocompatibility. In this study, we investigate the interaction of platelets from whole blood with surfaces coated with photochemically generated surface-attached polymer networks based on polydimethyl acrylamide.

Platelet repellent properties of hydrogel coatings on polyurethane-coated glass surfaces.

Thromboembolism is a severe complication in patients with ventricular assist devices. Interactions of platelets with the artificial surface and pathological blood flow conditions could contribute to thrombus formation. Previous studies suggested that strongly swellable polymer coatings prepared from various poly(N-alkyl acrylamides) are bioinert as they repel proteins and cells.

Fast and efficient MCR-based synthesis of clickable rhodamine tags for protein profiling.

Protein profiling probes are important tools for studying the composition of the proteome and as such have contributed greatly to the understanding of various complex biological processes in higher organisms. For this purpose the application of fluorescently labeled activity or affinity probes is highly desirable. Especially for in vivo detection of low abundant target proteins, otherwise difficult to analyse by standard blotting techniques, fluorescently labeled profiling probes are of high value.