Cytokine Inhibition in Patients With Chronic Fatigue Syndrome: A Randomized Trial.

Background: Interleukin-1 (IL-1), an important proinflammatory cytokine, is suspected to play a role in chronic fatigue syndrome (CFS).

Objective: To evaluate the effect of subcutaneous anakinra versus placebo on fatigue severity in female patients with CFS.

Design: Randomized, placebo-controlled trial from July 2014 to May 2016.

Cytokine inhibition in chronic fatigue syndrome patients: study protocol for a randomized controlled trial.

Background: Chronic fatigue syndrome (CFS) is a medically unexplained syndrome for which no somatic or pharmacological treatment has been proven effective. Dysfunction of the cytokine network has been suspected to play a role in the pathophysiology of CFS. The disturbances of the cytokine network detected in CFS patients are highly variable, in part due to the lack of adequate controls in many studies.