The Prediction of Tumorigenesis Onset Using Parameters from Chaotic Attractor Models.

Tumorigenesis can be modeled as a system of chaotic, nonlinear differential equations. From the analysis of these equations in state space, the onset of tumorigenesis can be predicted based on the status of parameters from the model.

The Development of Antisense RNA Treatments Using Engineered Protein Substrates.

Current efforts to design supercharged protein assemblies have opened the door for the creation of substrates that could be used for drug delivery and as substrates for antiviral delivery mechanisms. We explore the potential for antiviral delivery with antisense RNAs that bind their phosphate backbone to the charge of an engineered protein oligomer, providing structural integrity to the RNA strand and adding possible steric effects to prevent reaction with unintended targets.

The Effects of Quantum Entanglement on Chromatin and Gene Expression.

Quantum entanglement has recently been demonstrated in macroscopic structures at the scale of microns. The densely packed chromatin that efficiently stores DNA strands may allow for gene expression through epigenetic modifiers within the close proximity of nearby strands and may also experience gene expression through quantum entanglement of epigenetic modifiers. Such an approach may have an evolutionary advantage in the densely packed realm of chromatin.

Design of a Compensator Network to Stabilize Chaotic Tumor Growth.

Tumorigenesis can be modeled as a system of chaotic, nonlinear differential equations. From the analysis of these equations in state space, a feedback compensator is designed to stabilize the system based on a desired response. The feedback array constants represent four transducer molecules which could be used for any tumor type that obeys the same dynamics as the model, reducing drug investment requirements for a wider range of cancer treatment.

Chaotic attractors in tumor growth and decay: a differential equation model.

Tumorigenesis can be modeled as a system of chaotic nonlinear differential equations. A simulation of the system is realized by converting the differential equations to difference equations. The results of the simulation show that an increase in glucose in the presence of low oxygen levels decreases tumor growth.

The role of fungi in the etiology of chronic rhinosinusitis: a prospective study.

Objectives: Allergic fungal sinusitis (AFS) may represent an endpoint in a spectrum of sinonasal disease. Patients fulfilling criteria for a diagnosis of AFS have a poor prognosis often requiring multiple surgeries. The detection of 'allergic mucin' with mucus containing clusters of eosinophils and the detection of fungi by histological examination or culture is key criteria necessary for diagnosis.

Creutzfeldt-Jakob disease in Ireland: epidemiological aspects 1980-2002.

Surveillance for Creutzfeldt-Jakob disease (CJD) has been carried out in the Republic of Ireland since 1980. Initial surveillance was passive and based on consented autopsy confirmation of CJD in patients in whom there was a high index of clinical suspicion. Since 1999, an active surveillance programme involving formal notification of all suspect CJD cases has been in place.

vCJD risk in the Republic of Ireland.

Background: The Republic of Ireland has the second highest incidence of BSE worldwide. Only a single case of vCJD has been identified to date.

Methods: We estimate the total future number of clinical cases of vCJD using an established mathematical model, and based on infectivity of bovine tissue calculated from UK data and on the relative exposure to BSE contaminated meat.

A histological comparison of deep and superficial lobe pleomorphic adenomas of the parotid gland.

Background: Excision of parotid superficial lobe pleomorphic adenomas requires removal of a surrounding cuff of normal parotid tissue. Less aggressive dissection in removing pleomorphic adenomas that occur in the deep lobe of the parotid gland does not seem to compromise prognosis in these patients. We attempted to define histologic characteristics, differentiating superficial and deep lobe tumors, in an attempt to explain this clinical phenomenon.