Publications by authors named "Michael Harkisheimer"
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Synopsis of recent research by authors named "Michael Harkisheimer"
- Michael Harkisheimer's research primarily focuses on the structural biology of telomerase and its interactions, utilizing crystallography to understand the molecular mechanisms behind telomerase inhibition and activity.
- Significant findings include the discovery that the specific telomerase inhibitor BIBR1532 binds to a conserved hydrophobic pocket on the telomerase, and the identification of structural features in the telomerase complex that are essential for RNA binding and telomerase processivity.
- Harkisheimer's work also encompasses the reconstitution of active telomerase in vitro, and elucidation of the structure of the human telomeric Stn1-Ten1 capping complex, advancing knowledge on telomere maintenance in higher eukaryotes.
