The impact of biological sex and sex hormones on cognition in a rat model of early, pre-motor Parkinson's disease.

Parkinson's disease (PD) is well known for motor deficits such as bradykinesia. However, patients often experience additional deficits in working memory, behavioral selection, decision-making and other executive functions. Like other features of PD, the incidence and severity of these cognitive symptoms differ in males and females.

Vegfd can compensate for loss of Vegfc in zebrafish facial lymphatic sprouting.

Lymphangiogenesis is a dynamic process that involves the sprouting of lymphatic endothelial cells (LECs) from veins to form lymphatic vessels. Vegfr3 signalling, through its ligand Vegfc and the extracellular protein Ccbe1, is essential for the sprouting of LECs to form the trunk lymphatic network. In this study we determined whether Vegfr3, Vegfc and Ccbe1 are also required for development of the facial and intestinal lymphatic networks in the zebrafish embryo.

Stamps of Approval.

A multimedia artist has designed the first set of U.S. stamps ever painted on the computer.

Pushing Design to Its Limits.

About five years ago, architect and development manager George Hughes noticed that builders and developers would save a huge amount of money if they could somehow avoid producing prototypes before perfecting their designs. Visualizing the prototype in computer 3D space was clearly the answer, so Hughes approached Alias Research, obtained the necessary workstations and software, and founded Design Vision.