Sensitivity of candidate markers of psychophysiological strain to cyclical changes in manual control load during simulated process control.

Complex systems are vulnerable to unpredictable breakdowns in operator performance. Although primary task goals are typically protected by compensatory effort, such protection may break down under fatigue and high strain. Detection of strain states would enable prediction of increased operational risk through adaptive automation, triggering a switch of control from human to computer.

Dephosphorylation of Rb (Thr-821) in response to cell stress.

The retinoblastoma tumor suppressor Rb is regulated by reversible phosphorylation that is dependent upon cyclin-dependent kinase (CDK) and protein phosphatase type 1 (PP1) activity in replicating cells. Hyperphosphorylated Rb allows cells to proliferate, whereas the hypophosphorylated isoform of Rb inhibits proliferation. Of the many phosphorylation sites of Rb, there is functional information available for a very few.