Publications by authors named "Michael H J Maes"
Article Synopsis
- This systematic review aims to evaluate fMRI studies on bipolar disorder (BD) by comparing brain connectivity in BD patients with those having other psychiatric disorders and healthy individuals to identify potential diagnostic biomarkers.
- The review included 60 studies published since 2015, focusing on structural (20), functional (33), and effective (7) connectivity, following PRISMA guidelines for systematic reviews.
- Key findings reveal that BD is associated with abnormalities in specific brain areas like the frontal gyrus and cingulate cortex, while disrupted connectivity in networks related to emotion and reward, as well as in the salience, default mode, and executive control networks, suggests the potential for neuroimaging to serve as a diagnostic tool in the future.
Background: Temporal lobe epilepsy (TLE) is the most common focal epilepsy subtype in adults and is frequently accompanied by depression, anxiety and psychosis. Aberrations in total paraoxonase 1 (PON1) status may occur in TLE and these psychiatric conditions.
Aim: To examine PON1 status, namely Q192R PON1 genotypes and PON1 enzymatic activities, in TLE.
Objective: Psychoimmunological research in panic disorder (PD) so far focussed on single time point evaluation in resting conditions. No robust evidence for changes in the immune system was found using this method. However, PD is characterized by the occurrence of unexpected panic attacks (PAs).
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