Scientific basis and active ingredients of current therapeutic interventions for stroke rehabilitation.

Background: Despite tremendous advances in the treatment and management of stroke, restoring motor and functional outcomes after stroke continues to be a major clinical challenge. Given the wide range of approaches used in motor rehabilitation, several commentaries have highlighted the lack of a clear scientific basis for different interventions as one critical factor that has led to suboptimal study outcomes.

Objective: To understand the content of current therapeutic interventions in terms of their active ingredients.