Publications by authors named "Michael Giulbudagian"

Article Synopsis
  • - Tattooing has been part of human culture for thousands of years but has only recently become mainstream, sparking research into its health risks.
  • - The article discusses findings from a collaborative work published in The Lancet, focusing on adverse effects, treatment of complications, and regulations for public health improvements.
  • - The review emerges from the Second International Conference on Tattoo Safety, highlighting ongoing knowledge gaps and new insights into tattoo safety, regulatory strategies, and ink analysis.
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Article Synopsis
  • Magnetoplasmonic nanomaterials that respond to light and magnetic fields have great potential for medical applications, but creating these hybrid materials has been challenging due to compatibility issues between iron and gold.
  • This study presents a new method for synthesizing anisotropic magnetoplasmonic nanocomposites, using magnetic nanocubes made from iron oxide, zinc, and silver, which are then transformed into gold-based structures through a galvanic replacement process.
  • The resulting materials exhibit enhanced magnetic and photoconductive properties and show strong effectiveness for cell ablation under laser light, as well as capabilities as MRI contrast agents, indicating their promising use in biomedical fields.
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The continuous increase in the popularity of tattoos and permanent make-up (PMU) has led to substantial changes in their societal perception. Besides a better understanding of pathological conditions associated with the injection of highly diverse substances into subepidermal layers of the skin, their regulation has occupied regulatory bodies around the globe. In that sense, current regulatory progress in the European Union is an exemplary initiative for improving the safety of tattooing.

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Aluminium is one of the most abundant elements in earth's crust and its manifold uses result in an exposure of the population from many sources. Developmental toxicity, effects on the urinary tract and neurotoxicity are known effects of aluminium and its compounds. Here, we assessed the health risks resulting from total consumer exposure towards aluminium and various aluminium compounds, including contributions from foodstuffs, food additives, food contact materials (FCM), and cosmetic products.

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Polyglycerol-based thermoresponsive nanogels (tNGs) have been shown to have excellent skin hydration properties and to be valuable delivery systems for sustained release of drugs into skin. In this study, we compared the skin penetration of tacrolimus formulated in tNGs with a commercial 0.1% tacrolimus ointment.

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Novel nanogels that possess the capacity to change their physico-chemical properties in response to external stimuli are promising drug-delivery candidates for the treatment of severe skin diseases. As thermoresponsive nanogels (tNGs) are capable of enhancing penetration through biological barriers such as the stratum corneum and are taken up by keratinocytes of human skin, potential adverse consequences of their exposure must be elucidated. In this study, tNGs were synthesized from dendritic polyglycerol (dPG) and two thermoresponsive polymers.

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Engineered nanogels are of high value for a targeted and controlled transport of compounds due to the ability to change their chemical properties by external stimuli. As it has been indicated that nanogels possess a high ability to penetrate the stratum corneum, it cannot be excluded that nanogels interact with dermal dendritic cells, especially in diseased skin. In this study the potential crosstalk of the thermoresponsive nanogels (tNGs) with the dendritic cells of the skin was investigated with the aim to determine the immunotoxicological properties of the nanogels.

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Nanoparticles with a size of several hundred nanometers can effectively penetrate into the hair follicles and may serve as depots for controlled drug delivery. However, they can neither overcome the hair follicle barrier to reach the viable cells nor release the loaded drug adequately. On the other hand, small drug molecules cannot penetrate deep into the hair follicles.

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In this paper we present a comprehensive study for the ability of thermoresponsive nanogels (tNG) to act as cutaneous penetration enhancers. Given the unique properties of such molecular architectures with regard to their chemical composition and thermoresponsive properties, we propose a particular mode of penetration enhancement mechanism, i.e.

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