Publications by authors named "Michael G Grace"
Objective: To evaluate colonoscopies in patients aged 40 to 49 and 50 to 59 years from multiple endoscopy surgery centers serving a wide geographical area.
Methods: An observational prospective multicenter quality assurance review was conducted in 49 Ambulatory Surgery Centers in 17 states with 315 gastroenterologists. Care of patients and routine of gastroenterologists continued as standard practice with patients attending for purposes of screening, surveillance, and symptoms.
Article Synopsis
- Ursodeoxycholic acid (UDCA) is a bile acid used for treating gallstones and cholestatic liver diseases, but this study aimed to see if it could also lower cholesterol in patients with hypercholesterolemia without liver issues.
- A multicenter randomized, double-blind, placebo-controlled trial involved 134 eligible patients, who were assigned to either UDCA or placebo for 24 weeks after a 6-week placebo lead-in.
- Results indicated that UDCA did not significantly lower LDL cholesterol or other lipid levels compared to placebo, confirming it is not effective for type IIa or IIb hypercholesterolemia, though it was found to be safe and well tolerated.
Objective: To determine the demographic, clinical and microbiological characteristics of a representative Canadian obstetrical population.
Design: A one-year cohort study of all maternity patients who were followed to delivery, using detailed patient questionnaires containing more than 60 demographic and clinical variables, and three microbiological evaluations during gestation - first trimester, 26 to 30 weeks, and labour and delivery. Outcome measurements included birth weight and gestational age.
Objective: To determine the efficacy of fluoroscopically guided corticosteroid injection for hip osteoarthritis (OA) in a randomized, double-blind, placebo-controlled trial.
Methods: Fifty-two patients with symptomatic hip OA were randomly allocated to receive placebo (10 mg bipuvicaine, 2 ml saline) (n = 21) or corticosteroid treatment (10 mg bipuvicaine, 40 mg triamcinolone hexacetonide) (n = 31). Patients were followed up for 1, 2, 3, and 6 months.
Objective: Effects of angulation of computed tomography (CT) reconstruction plane on sacroiliac (SI) joint morphology were studied, and factors influencing the approach to fluoroscopically guided SI joint injection were assessed.
Design And Patients: CT scans of pelvises were reformatted on 41 subjects, aged 51.7 (+/-15.
Background: Barrett's esophagus (BE) may lead to high-grade dysplasia (HGD) and adenocarcinoma. The objective was to examine the impact of treating patients with BE and with HGD by using porfimer sodium (POR) and photodynamic therapy (PDT) for ablating HGD and reducing the incidence of esophageal adenocarcinoma.
Methods: The design was a multicenter, partially blinded (pathology), randomized clinical trial conducted in patients with BE who have HGD.
Recurrent infection with herpes simplex virus 1 (HSV1), called herpes simplex labialis (HSL), is a global problem for patients with normal immune systems. An effective management program is needed for those with frequent HSL recurrences, particularly if associated morbidity and life-threatening factors are present and the patient's immune status is altered. Over the past 20 years, a variety of antiviral compounds (acyclovir, penciclovir, famciclovir, valacyclovir) have been introduced that may reduce healing time, lesion size and associated pain.
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