Publications by authors named "Michael Feretis"
Article Synopsis
- Intraductal oncocytic papillary neoplasms (IOPNs) are now identified as distinct from intraductal papillary mucinous neoplasms (IPMNs), with limited information on their recurrence and survival outcomes.
- A study analyzed outcomes of 415 patients with invasive IOPNs and adenocarcinoma from IPMN over a median of 6 years, finding similar recurrence rates between invasive IOPNs and ductal A-IPMN, but poorer survival compared to colloid A-IPMN.
- The research concluded that invasive IOPNs behave like aggressive cancers, with adjuvant chemotherapy showing no significant impact on recurrence rates in any of the studied cancer types.
Article Synopsis
- The study examines the outcomes of different precursor epithelial subtypes of adenocarcinoma from intraductal papillary mucinous neoplasms (A-IPMN), focusing on clinical features and recurrence patterns among patients who underwent pancreatic surgery.
- A total of 297 patients were analyzed, revealing that gastric, pancreatobiliary, and mixed subtypes have similar outcomes that are worse than the intestinal subtype in terms of recurrence and overall survival.
- The research found that adjuvant chemotherapy specifically improved survival rates in the pancreatobiliary subtype, but not in gastric, intestinal, or mixed subtypes, indicating a potential area for further exploration in treatment strategies.
Article Synopsis
- - The study investigates factors affecting long-term survival and recurrence in patients with adenocarcinoma from intraductal papillary mucinous neoplasms, focusing on those who had pancreatic resection between 2010 and 2017 in Europe and Asia.
- - It analyzed data from 288 patients, revealing that 48% experienced recurrence within about 98 months, with 35% remaining disease-free at the 5-year mark.
- - Key negative predictors for long-term disease-free survival included multivisceral resection, tumor location in the pancreatic tail, poor differentiation, lymphovascular invasion, and perineural invasion, leading to the development of a predictive model with a good success rate.
Article Synopsis
- A study was conducted to determine the effects of adjuvant chemotherapy on patients with adenocarcinoma from intraductal papillary mucinous neoplasia after surgical resection, analyzing data from 459 patients across 18 centers between 2010 and 2020.
- The results showed that 59.9% of patients received various chemotherapy regimens, but there was no significant difference in recurrence rates or survival outcomes between those who received chemotherapy and those who did not.
- Overall, the study concluded that adjuvant chemotherapy does not appear to improve recurrence patterns or survival rates in this patient population.
Article Synopsis
- The study aimed to compare long-term cancer outcomes between patients with adenocarcinoma from intraductal papillary mucinous neoplasms (A-IPMN) and pancreatic ductal adenocarcinoma (PDAC) after surgical resection.
- Data revealed that A-IPMN patients generally had better survival rates and lower recurrence rates compared to PDAC patients, including longer median survival (39.0 months for A-IPMN vs. 19.5 months for PDAC).
- While A-IPMN showed higher rates of peritoneal and lung recurrence, PDAC had more locoregional recurrences, but overall, systemic recurrence rates were similar between the two groups.
Article Synopsis
- The study investigates recurrence patterns and treatment outcomes following pancreatic surgery for adenocarcinoma originating from intraductal papillary mucinous neoplasms (IPMN), involving 459 patients from multiple centers between 2010 and 2020.
- Recurrences were seen in 45.5% of patients, with a significant portion occurring within the first year, while the type of treatment did not significantly affect recurrence rates or survival based on location of the recurrence.
- Overall survival improved for patients receiving additional treatment post-recurrence, with a median survival of 27.0 months compared to 14.6 months without further treatment.
Liver regeneration biology: Implications for liver tumour therapies.
World J Clin Oncol
December 2021
The liver has remarkable regenerative potential, with the capacity to regenerate after 75% hepatectomy in humans and up to 90% hepatectomy in some rodent models, enabling it to meet the challenge of diverse injury types, including physical trauma, infection, inflammatory processes, direct toxicity, and immunological insults. Current understanding of liver regeneration is based largely on animal research, historically in large animals, and more recently in rodents and zebrafish, which provide powerful genetic manipulation experimental tools. Whilst immensely valuable, these models have limitations in extrapolation to the human situation.
View Article and Find Full Text PDFYttrium-90 radioembolization for unresectable hepatic metastases of breast cancer: A systematic review.
World J Gastrointest Oncol
February 2020
Background: Liver metastases secondary to breast cancer are associated with unfavourable prognosis. Radioembolization with ytrrium-90 is an emerging option for management of liver metastases of breast cancer when other systemic therapies have failed to achieve disease control. However, unlike the case of other liver tumours (colorectal/melanoma metastases/cholangiocarcinoma), its role in the management of breast liver metastases is yet to be elucidated.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to identify factors that predict survival after pancreaticoduodenectomy for ampullary cancer and to create a survival prediction model.
- It analyzed data from 110 patients treated between 2002 and 2013, categorizing them into three nodal subgroups based on the extent of cancer spread to lymph nodes.
- The results showed varying survival rates depending on the cancer staging, with vascular invasion and lymph node ratio identified as key independent predictors of survival, leading to the development of a prognostic model for clinical use.
Minimally invasive component separation techniques in complex ventral abdominal hernia repair: a systematic review of the literature.
Surg Laparosc Endosc Percutan Tech
April 2015
Purpose: Open component separation (CS) has traditionally been a popular method for management of complex abdominal wall hernias. However, it has been associated with significant wound complications. The aim of this systematic review was to examine the evidence in the literature on modern CS techniques (endoscopic and minimally invasive) for the management of such hernias.
View Article and Find Full Text PDFThe role of anorectal investigations in predicting the outcome of biofeedback in the treatment of faecal incontinence.
Scand J Gastroenterol
November 2013
Objective: The current literature does not provide unequivocal evidence on prognostic factors of patients' response to biofeedback for management of faecal incontinence. The aim of this study was to identify independent predictors of patient response to biofeedback.
Material And Methods: Baseline demographic characteristics, symptomatology and anorectal investigation reports of 137 patients who completed biofeedback therapy were analysed retrospectively.