Sixth-Hour Trancutaneous Bilirubin and Need for Phototherapy in DAT Positive Newborns.

Objectives: To characterize the outcomes of ABO incompatible direct antiglobulin test (DAT) positive newborns and determine the predictive ability of a sixth-hour transcutaneous bilirubin (TcB for needing phototherapy ≤24 hours of age.

Methods: Retrospective, cross-sectional study from May 2013 to March 2017. Of 10 942 consecutive newborns ≥35 weeks estimated gestational age, 829 were ABO incompatible and DAT positive.

The use of pulmonary clearance medications in the acutely ill patient.

Retention of airway secretions occurs in disease, leading to airway plugging, atelectasis, and worsened respiratory mechanics, making airway clearance an important therapeutic target. Areas covered: Many medications designed to enhance clearance of airway secretions are available. We will review the medications available to enhance airway clearance, their mechanisms of action, and the evidence available for their use in acutely ill patients.

Use of continuous renal replacement therapy in salicylate toxicity: A case report and review of the literature.

Objective: To report a case of salicylate toxicity treated with continuous venovenous hemodiafiltration (CVVHDF) and review the literature regarding the use of continuous renal replacement therapy (CRRT) for salicylate toxicity.

Case: A 16-year-old male presented after ingesting 1901 mg/kg of enteric coated aspirin. Salicylate level was 92 mg/dl 4 h after ingestion.

Drug hypersensitivity causing organizing eosinophilic pneumonia in a pediatric patient.

Objective: To describe a relatively rare hypersentivity reaction with pulmonary manifestations in a pediatric patient.

Data Sources: Electronic medical records.

Study Selection: Patient treatment in the pediatric critical care unit.

Blood cell exchange in the treatment of exercise-induced rhabdomyolysis in a patient with sickle cell trait.

We report the use of red blood cell exchange (RBCex) to treat rhabdomyolysis complicated by acute kidney injury in a 16-year-old African-American female with sickle cell trait (SCT). Treatment with aggressive fluid and electrolyte management failed to stem the rise in her creatine kinase, and RBCex was instituted 27 hours after symptom onset. She had a transient improvement in her creatine kinase following this treatment although it failed to resolve a developing lower extremity compartment syndrome, requiring bilateral lower extremity fasciotomies.