Attempted depletion of passenger leukocytes by irradiation in pigs.

Allograft/xenograft rejection is associated with "passenger leukocyte" migration from the organ into recipient lymph nodes. In Study 1, we attempted to deplete leukocytes from potential kidney "donor" pigs, using two regimens of total body irradiation. A dose of 700 cGy was administered, followed by either 800 cGy ("low-dose") or 1,300 cGy ("high dose") with the kidneys shielded.