Publications by Michael El Beyrouthy

Publications by authors named "Michael El Beyrouthy"

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DNA-PK controls Apollo's access to leading-end telomeres.

Ceylan Sonmez Beatrice Toia Patrik Eickhoff Andreea Medeea Matei Michael El Beyrouthy

Nucleic Acids Res

May 2024

The complex formed by Ku70/80 and DNA-PKcs (DNA-PK) promotes the synapsis and the joining of double strand breaks (DSBs) during canonical non-homologous end joining (c-NHEJ). In c-NHEJ during V(D)J recombination, DNA-PK promotes the processing of the ends and the opening of the DNA hairpins by recruiting and/or activating the nuclease Artemis/DCLRE1C/SNM1C. Paradoxically, DNA-PK is also required to prevent the fusions of newly replicated leading-end telomeres.

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- Michael El Beyrouthy's recent research primarily focuses on the role of DNA-dependent protein kinase (DNA-PK) in maintaining genomic stability, specifically in the context of telomere protection and double strand break repairs.
- In his latest article, "DNA-PK controls Apollo's access to leading-end telomeres," he investigates how the Ku70/80-DNA-PKcs complex facilitates the synapsis and joining of double strand breaks during canonical non-homologous end joining (c-NHEJ) and its paradoxical role in preventing telomere fusions.
- The findings suggest a complex regulatory mechanism where DNA-PK is essential for both the efficient repair of DSBs and the safeguarding of newly replicated leading-end telomeres, highlighting its dual functions in genome maintenance.

Publications by authors named "Michael El Beyrouthy"

DNA-PK controls Apollo's access to leading-end telomeres.

Synopsis of recent research by authors named "Michael El Beyrouthy"