Publications by authors named "Michael Edwards"
Background: Same-day discharge after sleeve gastrectomy (SDDSG) is being performed in select patient populations with increased regularity since 2020.
Objectives: To evaluate the impact of SDDSG on emergency department (ED) visits.
Setting: Academic and private practice bariatric surgery programs participating in a statewide quality improvement collaborative.
Background: There are few reported outcomes of treatment of acute cholecystitis incorporating current guidelines for gallbladder dissection techniques and use of percutaneous tube cholecystostomy (PCT). The authors hypothesize PCT allows regression of peritoneal inflammation, but infundibular inflammation is increased at interval cholecystectomy, resulting in greater requirement for advanced dissection techniques.
Methods: Between December 2009 and July 2023, 1222 patients were admitted with acute cholecystitis and ultimately underwent cholecystectomy.
Cilomilast, a phosphodiesterase-4 (PDE4) selective inhibitor, has anti-inflammatory effects in vitro and in vivo and reduces COPD exacerbations. We tested the hypothesis that cilomilast inhibits virus-induced airway epithelial intercellular adhesion molecule-1 (ICAM-1) expression and inflammatory cytokine/chemoattractants, IL-6, CXCL8, and CCL5 production in vitro. BEAS-2B bronchial epithelial cells were incubated with 0.
View Article and Find Full Text PDFImpaired antiviral immunity in frequent exacerbators of chronic obstructive pulmonary disease.
Am J Physiol Lung Cell Mol Physiol
January 2025
Article Synopsis
- - Respiratory viruses, especially rhinoviruses, contribute to exacerbations of chronic obstructive pulmonary disease (COPD), with some patients experiencing frequent flare-ups (≥2 per year).
- - A study found that COPD patients had significantly reduced responses of interferons (IFNs) in their alveolar macrophages, particularly those with frequent exacerbations compared to infrequent ones and healthy individuals.
- - Pro-inflammatory cytokines were elevated in uninfected bronchial epithelial cells (BECs) from COPD patients; however, the response to viral infection did not differ between COPD patients and healthy subjects.
Permissive weight bearing versus restrictive weight bearing in surgically treated trauma patients with displaced intra-articular calcaneal fractures (the PIONEER study): study protocol for a multicenter randomized controlled trial.
Trials
November 2024
Article Synopsis
- This study investigates rehabilitation approaches for patients with surgically treated displaced intra-articular calcaneal fractures (DIACFs), comparing permissive weight bearing (PWB) and restricted weight bearing (RWB) protocols to identify the best option for recovery and overall health outcomes.
- A randomized controlled trial will involve 115 patients aged 18-67, assessing primary functional outcomes via the American Orthopaedic Foot & Ankle Society Score (AOFAS) and secondary outcomes including quality of life and cost-effectiveness.
- The goal is to determine if the PWB protocol is at least as effective as the RWB protocol in terms of safety and recovery, with follow-ups scheduled at specific intervals over
Article Synopsis
- The demand for graphene-related 2D materials (GR2Ms) is increasing, so the industry needs reliable, easy-to-use quality measurement methods for production.
- The paper highlights the use of hydrogen nuclear magnetic resonance (NMR) relaxation and Raman spectroscopy as effective techniques for real-time quality monitoring of GR2Ms.
- NMR relaxation can deliver results in under a minute, while Raman spectroscopy offers continuous data collection during production, improving overall quality control compared to traditional lab methods.
Cast-OFF 2: one week versus three to five weeks of plaster cast immobilization for non-or minimally displaced distal radius fractures, a stepped wedge cluster randomized controlled trial.
J Orthop Trauma
October 2024
Article Synopsis
- The study aimed to evaluate the efficacy of shortening the cast immobilization period for distal radius fractures (DRF) from 3-5 weeks to 1 week followed by gradual mobilization.
- Conducted in various trauma centers, it involved randomly assigning hospitals to either the usual care or the shorter immobilization method, with patients aged 18 to 85 included if they had isolated, non- or minimally displaced DRF.
- Results showed no significant differences in functional outcomes, pain scores, or patient satisfaction between the two groups, suggesting that the shorter immobilization period may be equally effective as the conventional approach.
Article Synopsis
- Researchers are investigating whether activating the STING pathway causes lung inflammation that resembles severe asthma, particularly by focusing on neutrophilic responses.
- They developed models using house dust mites and STING agonists to study inflammation effects on mice and human cells, measuring various inflammatory markers and lung function.
- The findings suggest that STING activation leads to increased airway hyperresponsiveness and cell death, resembling severe asthma features and indicating a mixed immune response involving type 1 neutrophils.
Background: Metabolic and bariatric surgery (MBS) is the most durable treatment of obesity and can reduce statin use.
Objective: We compare statin use trajectories in patients with and without MBS.
Methods: Adults with a body mass index ≥ 35kg/m were identified using a U.
Article Synopsis
- One anastomosis gastric bypass (OAGB) is gaining popularity and needs a thorough safety evaluation compared to Roux-en-Y gastric bypass (RYGB).
- A study matched 1,569 patients who had OAGB with 6,276 RYGB patients, finding OAGB to have lower complication rates, shorter operation times, and reduced hospital stays.
- Results indicated that OAGB led to significant improvements, such as a 27% decrease in overall complications and a notably lower rate of bowel obstructions compared to RYGB.
Kv1.3 is a multifunctional potassium channel implicated in multiple pathologies, including cancer. However, how it is involved in disease progression is not fully clear.
View Article and Find Full Text PDFArticle Synopsis
- * The protein was successfully expressed in a common yeast, retaining its sweet taste and structure, despite the truffle being hard to cultivate.
- * Preliminary safety tests suggest HTS is nonallergenic, nontoxic, and easily digestible, making it a promising alternative to traditional sugars and artificial sweeteners in food production.
Background: Clinical care pathways help guide and provide structure to clinicians and providers to improve healthcare delivery and quality. The Quality Improvement and Patient Safety Committee (QIPS) of the American Society for Metabolic and Bariatric Surgery (ASMBS) has previously published care pathways for the performance of laparoscopic sleeve gastrectomy (LSG) and pre-operative care of patients undergoing Roux-en-Y gastric bypass (RYGB).
Objective: This current RYGB care pathway was created to address intraoperative care, defined as care occurring on the day of surgery from the preoperative holding area, through the operating room, and into the postanesthesia care unit (PACU).
Many scales used in psychological and health research are designed to yield subscores, yet it is common to see total scores reported instead. One challenge of using subscores is they can lack adequate reliability due to their shortened length. However, methods originally developed for educational measurement have shown that augmenting subscores can improve reliability estimates.
View Article and Find Full Text PDFArticle Synopsis
- Insomnia is a common problem for kids with autism, making it hard for them to fall or stay asleep.
- Researchers created a new tool called the Pediatric Autism Insomnia Rating Scale to help understand and measure sleep issues in autistic children, collecting data from 1185 kids.
- The scale was tested and proved to accurately measure sleep problems, showing stable results over time, so it's a reliable way to assess insomnia in children with autism.
Sphingosine has been previously shown to kill many strains of pathogenic bacteria including Pseudomonas aeruginosa, Staphyloccus aureus, Acinetobacter, and atypical mycobacteria. However, these studies were performed on isolated or extracellular bacteria and it is unknown whether sphingosine also targets intracellular bacteria. Here, we demonstrate that exogenously-added sphingosine directly binds to extracellular P.
View Article and Find Full Text PDFBackground: The Society of Black Academic Surgeons (SBAS) sought to understand who constitutes its membership and obtain feedback to improve the organization.
Methods: SBAS conducted a 25-question survey amongst members.
Results: The response rate was 19 % (n = 132/685) with an even gender breakdown (male n = 64, female n = 68).
Background: Sleeve gastrectomy (SG) remains a safe and effective treatment for severe obesity. The number of robotic SG (RSG) has steadily increased from 2015 to 2021. Prior studies have shown higher rates of some adverse outcomes with RSG but have not accounted for staplers used.
View Article and Find Full Text PDFSymmetry of the left and right tibial plafond; a comparison of 75 distal tibia pairs.
Eur J Trauma Emerg Surg
December 2024
Purpose: Tibia plafond or pilon fractures present a high level of complexity, making their surgical management challenging. Three-Dimensional Virtual Planning (3DVP) can assist in preoperative planning to achieve optimal fracture reduction. This study aimed to assess the symmetry of the left and right tibial plafond and whether left-right mirroring can reliably be used.
View Article and Find Full Text PDFArticle Synopsis
- Obesity is a growing issue globally, prompting interest in bariatric surgery, but there's a lack of understanding regarding the demographics represented in clinical trials for these procedures.
- Analyzing 117 clinical trials with over 8,400 participants revealed that most were middle-aged (average age 43.8), predominantly female (74.9%), and primarily White (65.3%), with very few participants from diverse racial and ethnic backgrounds.
- The findings highlight significant demographic disparities in bariatric surgery trials, underscoring the importance of inclusive recruitment to improve overall health equity in surgical interventions.*
Background: While racial disparity in surgical mortality due to venous thromboembolism (VTE) has improved, a gap persists. Our study aim was to determine differences in VTE prevention practices and their impact on outcomes among racial surgical cohorts.
Methods: Elective surgeries performed between 1.
Background: Sleeve gastrectomy (SG) is an effective treatment option for patients with obesity. Robotic sleeve gastrectomy (RSG) is reported to have worse short-term patient outcomes compared to laparoscopic SG (LSG), but prior studies may not have accounted for evolving technology, including stapler utilization.
Objective: This study compared RSG and LSG outcomes over different time periods.