Publications by authors named "Michael E Placke"
Nucleic Acid Ther
December 2016
Article Synopsis
- Registration of pharmaceuticals needs testing for genotoxic risk using established guidelines, and the study found that diverse siRNA-GalNAc conjugates showed consistently negative results across these tests.
- The study examined siRNA-GalNAc conjugates in various assays, confirming their internalization in cells and bacteria, and showed significant uptake levels post-exposure.
- Additional assays corroborated negative genotoxicity findings, including chromosome aberration tests and a double-strand DNA break assay, affirming the safety profile of these siRNA conjugates.
