Publications by authors named "Michael E Haws"
Article Synopsis
- - A female patient with developmental regression shows a de novo mutation in the CACNA1A gene, which is linked to other conditions but not traditionally associated with Rett syndrome.
- - She meets several criteria for atypical Rett syndrome, specifically showing symptoms like stereotypic hand movements and gait disturbance, along with multiple supportive symptoms.
- - The authors suggest that CACNA1A mutations may play a role in atypical Rett syndrome presentations, particularly in cases resembling the early seizure variant.
Mutations in phosphatase and tensin homolog deleted on chromosome 10 (PTEN) are implicated in neuropsychiatric disorders including autism. Previous studies report that PTEN knockdown in neurons in vivo leads to increased spine density and synaptic activity. To better characterize synaptic changes in neurons lacking PTEN, we examined the effects of shRNA knockdown of PTEN in basolateral amygdala neurons on synaptic spine density and morphology by using fluorescent dye confocal imaging.
View Article and Find Full Text PDFAgricultural and household organophosphorus (OP) pesticides inhibit acetylcholinesterase (AchE), resulting in increased acetylcholine (Ach) in the central nervous system. In adults, acute and prolonged exposure to high doses of AchE inhibitors causes severe, clinically apparent symptoms, followed by lasting memory impairments and cognitive dysfunction. The neurotoxicity of repeated environmental exposure to lower, subclinical doses of OP pesticides in adults is not as well studied.
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