Publications by authors named "Michael Dunlavey"
Evaluation of performance of distributed delay model for chemotherapy-induced myelosuppression.
J Pharmacokinet Pharmacodyn
April 2018
Article Synopsis
- The distributed delay model improves upon the classic model for chemotherapy-induced myelosuppression by using a convolution integral to describe the maturation of granulocyte precursors in the bone marrow.
- This new model demonstrated significantly better performance than the classic model when analyzing white blood cell count data in rats treated with 5-fluorouracil, particularly in terms of log-likelihood.
- However, it required much longer computational time due to the complexity of evaluating the convolution integral, while still being reliably identifiable from cytotoxic data.
A distributed delay approach for modeling delayed outcomes in pharmacokinetics and pharmacodynamics studies.
J Pharmacokinet Pharmacodyn
April 2018
Article Synopsis
- A new distributed delay approach for modeling delayed outcomes in pharmacokinetics and pharmacodynamics studies was introduced, allowing flexibility in a variety of related models.
- This method can accommodate both typical and atypical absorption models, including zero-order and first-order absorption processes.
- The paper also provides practical examples using the software Phoenix NLME™ 8.0, highlighting the benefits of this approach compared to traditional modeling techniques.