Publications by authors named "Michael Doney"
Article Synopsis
- A 3-year precision medicine study involved 1,190 adults undergoing whole-genome sequencing and deep phenotyping to understand genetic risks associated with various diseases.
- Out of the participants, 17.3% had identified genetic variants indicating a predisposition to diseases, with significant genotype-phenotype associations found primarily in cardiovascular and metabolic conditions.
- The study highlights the integration of genomic data with detailed phenotypic information to improve clinical assessments, revealing both associations and instances with no discernible connections in some individuals despite pathogenic variants.
Background: Aortoenteric fistula (AEF) is a rare but life-threatening condition in which expedient diagnosis is often difficult. It arises from erosion of a segment of aorta, usually an abdominal aortic aneurysm, into an adjacent portion of the gastrointestinal tract or between a vascular graft of the aorta and an adjacent portion of the gastrointestinal tract. It can present as life-threatening upper or lower gastrointestinal bleeding and is a surgical emergency that requires rapid assessment, emergency resuscitation, and definitive treatment.
View Article and Find Full Text PDFFunding emergency medicine development in low- and middle-income countries.
Emerg Med Clin North Am
February 2005
The specialty of EM is developing rapidly throughout the world. This growth is relatively lacking in the LICs, however. The lack of resources and financing capabilities in these regions may hinder specialty development.
View Article and Find Full Text PDFThere are a number of notable trends in the development of EM that have been highlighted at the regional level globally. From the establishment of formal EM training as the standard of care to practice in an ED to the influence of transnational regulatory bodies and financing mechanisms on specialty development and the broad-based issues of health security that affect EM, the specialty continues to grow around the world. As practitioners in each of these regions struggle to respond effectively to the development issues and challenges presented here, they continue to advance EM as one of the more dynamic young specialties in medicine.
View Article and Find Full Text PDFStudy Objective: We determine the incidence of desaturation and pulse rate reactivity during paramedic rapid sequence intubation of patients with severe head injuries (Glasgow Coma Scale score
Methods: Adult patients with severe head injuries had recording oximeter-capnometers applied before rapid sequence intubation. Desaturation was defined as a reduction in oxygen saturation (Spo(2)) to less than 90% from an initial Spo(2) of greater than or equal to 90% or a decrease from a baseline of less than 90%.