Long-time emergent dynamics of liquid films undergoing thermocapillary instability.

The study of viscous thin film flow has led to the development of highly nonlinear partial differential equations that model how the evolution of the film height is affected by different forces. We investigate a model of interaction between surface tension and the thermocapillary Marangoni effect, with a particular focus on the long-time limit. In this limit, the model predicts the creation of an infinite cascade of successively smaller satellite droplets near points where the film thickness vanishes.

The effect of chemotaxis on T-cell regulatory dynamics.

Autoimmune diseases, such as Multiple Sclerosis, are often modelled through the dynamics of T-cell interactions. However, the spatial aspect of such diseases, and how dynamics may result in spatially heterogeneous outcomes, is often overlooked. We consider the effects of diffusion and chemotaxis on T-cell regulatory dynamics using a three-species model of effector and regulator T-cell populations, along with a chemical signalling agent.

Examining the efficacy of localised gemcitabine therapy for the treatment of pancreatic cancer using a hybrid agent-based model.

The prognosis for pancreatic ductal adenocarcinoma (PDAC) patients has not significantly improved in the past 3 decades, highlighting the need for more effective treatment approaches. Poor patient outcomes and lack of response to therapy can be attributed, in part, to a lack of uptake of perfusion of systemically administered chemotherapeutic drugs into the tumour. Wet-spun alginate fibres loaded with the chemotherapeutic agent gemcitabine have been developed as a potential tool for overcoming the barriers in delivery of systemically administrated drugs to the PDAC tumour microenvironment by delivering high concentrations of drug to the tumour directly over an extended period.

Interfacial dynamics and pinch-off singularities for axially symmetric Darcy flow.

We study a model for the evolution of an axially symmetric bubble of inviscid fluid in a homogeneous porous medium otherwise saturated with a viscous fluid. The model is a moving boundary problem that is a higher-dimensional analog of Hele-Shaw flow. Here we are concerned with the development of pinch-off singularities characterized by a blowup of the interface curvature and the bubble subsequently breaking up into two; these singularities do not occur in the corresponding two-dimensional Hele-Shaw problem.

Discrete Self-Similarity in Interfacial Hydrodynamics and the Formation of Iterated Structures.

The formation of iterated structures, such as satellite and subsatellite drops, filaments, and bubbles, is a common feature in interfacial hydrodynamics. Here we undertake a computational and theoretical study of their origin in the case of thin films of viscous fluids that are destabilized by long-range molecular or other forces. We demonstrate that iterated structures appear as a consequence of discrete self-similarity, where certain patterns repeat themselves, subject to rescaling, periodically in a logarithmic time scale.

A curve shortening flow rule for closed embedded plane curves with a prescribed rate of change in enclosed area.

Motivated by a problem from fluid mechanics, we consider a generalization of the standard curve shortening flow problem for a closed embedded plane curve such that the area enclosed by the curve is forced to decrease at a prescribed rate. Using formal asymptotic and numerical techniques, we derive possible extinction shapes as the curve contracts to a point, dependent on the rate of decreasing area; we find there is a wider class of extinction shapes than for standard curve shortening, for which initially simple closed curves are always asymptotically circular. We also provide numerical evidence that self-intersection is possible for non-convex initial conditions, distinguishing between pinch-off and coalescence of the curve interior.

Saffman-Taylor fingers with kinetic undercooling.

The mathematical model of a steadily propagating Saffman-Taylor finger in a Hele-Shaw channel has applications to two-dimensional interacting streamer discharges which are aligned in a periodic array. In the streamer context, the relevant regularization on the interface is not provided by surface tension but instead has been postulated to involve a mechanism equivalent to kinetic undercooling, which acts to penalize high velocities and prevent blow-up of the unregularized solution. Previous asymptotic results for the Hele-Shaw finger problem with kinetic undercooling suggest that for a given value of the kinetic undercooling parameter, there is a discrete set of possible finger shapes, each analytic at the nose and occupying a different fraction of the channel width.