Publications by authors named "Michael D Ryks"
Article Synopsis
- The study investigated how ondansetron affects patients with diabetic gastroenteropathy (DGE) compared to a placebo.
- Patients took ondansetron or a placebo for 4 weeks, and their symptoms and gastric emptying were monitored through various methods.
- Ondansetron reduced feelings of fullness and belching during lipid infusions but did not significantly affect daily symptoms compared to placebo, although some patients showed potential for symptom improvement when ondansetron was effective during the lipid challenge.
Dose-response effect of a beta3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health.
Am J Physiol Gastrointest Liver Physiol
May 2008
beta(3)-Adrenoceptors(beta(3)-AR) are expressed by cholinergic myenteric neurons and beta(3)-AR agonists are effective in experimental models of diarrhea. Our aim was to explore the effects of a beta(3)-AR agonist, solabegron, on gastrointestinal transit, safety, bowel function, plasma somatostatin, and solabegron pharmacokinetics (PK) following single and multiple doses. In a single-center, double-blind, parallel-group trial, 36 healthy volunteers were randomized to oral solabegron (50 or 200 mg twice daily) or placebo.
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