Compliance with estrogen hormone replacement therapy after oophorectomy: a prospective study.

Objective: To quantify compliance with using estrogen-only hormone replacement therapy (HRT) up until the time of mean age of natural menopause in women undergoing either bilateral oophorectomy or removal of one remaining ovary at the time of hysterectomy for benign disease.

Design: Prospective study. Annual questionnaire follow-up for ten years of women undergoing hysterectomy and bilateral oophorectomy for benign disease aged 46 or less at the time of surgery.

The age of ovarian failure following premenopausal hysterectomy with ovarian conservation.

Objective: To test the hypothesis that premenopausal hysterectomy compromises ovarian function and accelerates ovarian failure.

Design: Longitudinal prospective cohort study. Annual follow-up with serum follicle-stimulating hormone levels with all women being 46 years of age or less at the time of hysterectomy for benign disease.