Browse Categories

Publications by authors named "Michael D Hood"

  • Page 1 of 1
Targeted tissue delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs).
Barbora Malecova Rob S Burke Michael Cochran Michael D Hood Rachel Johns

Nucleic Acids Res

July 2023

Although targeting TfR1 to deliver oligonucleotides to skeletal muscle has been demonstrated in rodents, effectiveness and pharmacokinetic/pharmacodynamic (PKPD) properties remained unknown in higher species. We developed antibody-oligonucleotide conjugates (AOCs) towards mice or monkeys utilizing anti-TfR1 monoclonal antibodies (αTfR1) conjugated to various classes of oligonucleotides (siRNA, ASOs and PMOs). αTfR1 AOCs delivered oligonucleotides to muscle tissue in both species.

View Article and Find Full Text PDF
Privacy Policy Site Map

© LitMetric 2024. All rights reserved.

A PHP Error was encountered

Severity: Warning

Message: fopen(/var/lib/php/sessions/ci_sessionp1bdoqre8c500i75m2r44025qnosrfr3): Failed to open stream: No space left on device

Filename: drivers/Session_files_driver.php

Line Number: 177

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once

A PHP Error was encountered

Severity: Warning

Message: session_start(): Failed to read session data: user (path: /var/lib/php/sessions)

Filename: Session/Session.php

Line Number: 137

Backtrace:

File: /var/www/html/index.php
Line: 316
Function: require_once