Publications by authors named "Michael Comisac"
Objective: To describe the clinical features of a cohort of individuals with stiff person syndrome spectrum disorders (SPSD) and identify potential early predictors of future disability.
Background: There is a need to better understand the full spectrum of clinical and paraclinical features and long-term impact of SPSD.
Design/methods: Observational study from 1997 to 2022 at Johns Hopkins.
Article Synopsis
- Stiff Person Syndrome Spectrum Disorders (SPSD) are rare neurological conditions that often occur with other autoimmune diseases, but little is known about their related non-neurological autoantibodies and comorbidities.
- This study analyzed data from 205 SPSD patients at Johns Hopkins Hospital over 26 years to investigate the prevalence of these autoantibodies and any associated autoimmune conditions.
- Results showed the majority of patients had classic SPS, with common non-neurological autoantibodies identified as anti-nuclear and thyroid-related, while prevalent comorbidities included autoimmune thyroiditis and diabetes, highlighting a significant burden in this patient population.
Introduction: The effect of stiff person syndrome spectrum disorders (SPSD) on the gastrointestinal tract (GIT) is unknown. This case series aims to characterize the prevalence and types of GI dysfunction in individuals with SPSD.
Methods: A retrospective chart review included individuals diagnosed with SPSD with descriptors of GI symptoms in their medical records.