Publications by authors named "Michael Cieza"

Cryoglobulins are immunoglobulins that precipitate at temperatures below 37 °C and dissolve upon reheating. They can induce small-vessel vasculitis with renal involvement. Cryoglobulinemic glomerulonephritis is a rare manifestation that occurs in patients with monoclonal gammopathy, specifically Waldenström's macroglobulinemia.

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Introduction: Cryoglobulinemia refers to the presence of cryoglobulins (CGs) in the serum, encompassing a group of diseases caused by the type of circulating GC. Cryoglobulinemic glomerulonephritis (CryoGN) is the principal manifestation of renal involvement. The diagnosis may be challenging because the hallmark of cryoglobulinemia is the detection of CG in the serum.

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Article Synopsis
  • SGLT-2 inhibitors (SGLT-2i) are becoming the recommended treatment for diabetic kidney disease (DKD), but previous research often excluded patients on kidney replacement therapy (KRT).
  • A study followed seven diabetic patients on incremental hemodialysis for a year and found that all of them maintained their residual kidney function (RKF) and experienced significant improvements in kidney health and blood pressure.
  • While some patients had minor side effects like urinary tract infections, the overall use of SGLT-2i appeared to be safe and effective for preserving RKF in this patient group.
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