Publications by authors named "Michael Chatigny"
Article Synopsis
- Parkinson's Disease (PD) is a serious brain disorder affecting over 1% of people over 60, leading to issues with movement and thinking, but its exact causes are still unclear.
- To investigate the complexity of PD, researchers conducted single-nucleus RNA sequencing and whole-genome sequencing on 100 postmortem samples, selecting cases that represent varying stages and symptoms of the disease.
- The resulting dataset, created with high standards of quality control, is freely available on the AMP PD Knowledge Platform, facilitating research into the molecular mechanisms of PD and potentially helping to improve treatment options.
Introduction: Transdiagnostic dimensional phenotypes are essential to investigate the relationship between continuous symptom dimensions and pathological changes. This is a fundamental challenge to work, as assessments of phenotypic concepts need to rely on existing records.
Methods: We adapted well-validated methodologies to compute National Institute of Mental Health Research Domain Criteria (RDoC) scores using natural language processing (NLP) from electronic health records (EHRs) obtained from brain donors and tested whether cognitive domain scores were associated with Alzheimer's disease neuropathological measures.
Introduction: Transdiagnostic dimensional phenotypes are essential to investigate the relationship between continuous symptom dimensions and pathological changes. This is a fundamental challenge to postmortem work, as assessment of newly developed phenotypic concepts needs to rely on existing records.
Methods: We adapted well-validated methodologies to compute NIMH research domain criteria (RDoC) scores using natural language processing (NLP) from electronic health records (EHRs) obtained from post-mortem brain donors and tested whether RDoC cognitive domain scores were associated with hallmark Alzheimer's disease (AD) neuropathological measures.