Publications by authors named "Michael Chas Sumner"
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Synopsis of recent research by authors named "Michael Chas Sumner"
- Michael Chas Sumner's research emphasizes the role of the nuclear pore complex (NPC) in transcription regulation, highlighting how NPC interactions can both repress and activate transcription, as well as influence gene spatial arrangement and clustering within the nucleus
- His findings reveal that genes clustered at the nuclear periphery exhibit reduced dynamics due to sub-diffusion and capture by the NPC, facilitating coordinated inter-chromosomal movements among co-regulated loci
- The work also explores how transcription factor binding sites are essential for targeting active genes to the NPC, suggesting that gene positioning and interchromosomal clustering are intricately regulated processes influenced by transcription factors
