Publications by authors named "Michael Canova Engelbrecht Nielsen"

Background: Acne vulgaris stands as a prevailing skin condition among adolescents worldwide.

Objectives: The primary aim in addressing acne is to manage it effectively, preventing the occurrence of permanent scarring.

Materials And Methods: This case report outlines the experiences of two adolescent boys grappling with acne fulminans.

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Background: Rosacea is a difficult-to-manage chronic inflammatory skin condition reported to have a negative psychosocial impact on patients. Novel approaches are sought to target the many signs and symptoms of the condition while also improving the quality of life of patients.

Objective: We assessed the efficacy of the Kleresca biophotonic platform (KLOX Technologies Inc.

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Skin grafting is often the only treatment for skin trauma when large areas of tissue are affected. This surgical intervention damages the deeper dermal layers of the skin with implications for wound healing and a risk of scar development. Photobiomodulation (PBM) therapy modulates biological processes in different tissues, with a positive effect on many cell types and pathways essential for wound healing.

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Fluorescent light energy therapy combined with low-dose isotretinoin or tetracycline show remarkable clinical effect on 12 cases of moderate-to-severe acne. Treatment was considered safe, well-tolerated, and highly efficacious.

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We present a novel treatment for removal of SL that is efficient and enables removal or lesions not immediately visible. Kleresca FLE technology combined with picosecond laser treatment removes SL lesions and improves skin quality and appearance.

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The Kleresca biophotonic platform utilizing fluorescent light energy (FLE) effectively treated both acne conglobata and hidradenitis suppurativa. FLE decreased the presence of inflammatory nodules, cysts, and associated erythema. It also supported a healing response to improve skin texture.

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We have previously reported clinical efficacy with a novel form of photobiomodulation-a biophotonic platform inducing fluorescent light energy (FLE)-in both disease-affected and healthy skin; however, the cellular mechanisms remain largely unknown. This study investigated the cellular mechanism of action of FLE on key skin and immune cells. We examined the effects of FLE on the clinical presentation of inflammation in a representative patient with acne vulgaris.

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Kleresca® biophotonic platform utilizing fluorescent light energy effectively decreased the inflammatory and erythematous reaction common in rosacea subtypes 1, 2, and 3. Kleresca® may be considered as a single treatment for rosacea, targeting multiple features, or combined with invasive methods for an enhanced normalizing and healing profile of the skin.

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Treating solar lentigines using picosecond-switched lasers that selectively remove the excess pigment was combined with Kleresca biophotonic treatment. This therapy uses fluorescent light energy to stimulate healing by increasing collagen production and reducing inflammation. Combining these therapies successfully removed solar lentigines and achieved normalized and rejuvenated treated skin.

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