Publications by authors named "Michael C Rigor"
Neutrophil elastase (NE) plays a pivotal role in inflammation. However, the mechanism underlying NE-mediated inflammation in obesity remains unclear. Here, we report that NE activates protease-activated receptor-2 (PAR2), stimulates actin filament (F-actin) formation, decreases intercellular junction molecule VE-cadherin expression, and increases the permeability of human arterial endothelial cells (hECs).
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- CDP138 is a protein crucial for membrane trafficking and is linked to metabolism; mice lacking this protein develop obesity on both regular and high-fat diets.
- These CDP138-deficient mice have reduced energy expenditure, lower oxygen consumption, and decreased body temperature compared to normal mice, impacting their overall metabolism.
- Additionally, the absence of CDP138 affects catecholamine levels, reducing fat tissue browning and thermogenesis, which makes these mice more susceptible to insulin resistance when on a high-fat diet.