Publications by authors named "Michael C McHale"
Proc Natl Acad Sci U S A
April 2022
Article Synopsis
- High-grade serous ovarian cancer (HGSOC) is a deadly cancer type known for a lack of immune response, indicated by the low presence of tumor infiltrating lymphocytes (TILs) and poor responses to immunotherapy.
- Research found that active FAK (focal adhesion kinase), which is linked to poor survival rates and prevalent in about 70% of HGSOC cases, correlates with reduced levels of TILs and increased expression of immune checkpoint ligands like CD155.
- Using a mouse model, the study revealed that inhibiting FAK not only reduced tumor size and associated immune responses but also enhanced the effectiveness of combining FAK inhibitors with TIGIT-blocking antibodies, suggesting a new immunotherapy strategy for H
