Proteomic profiling of pretreatment serum from HIV-infected patients identifies candidate markers predictive of lymphoma development.

Objective: HIV-infected individuals have an increased risk of developing lymphoma. We sought to identify markers predictive of lymphoma development by comparing protein expression patterns in serum obtained at the time of HIV diagnosis from patients who later developed malignant lymphoma or benign lymphadenopathy, with samples from patients with no subsequent history of neoplasia.

Design: All patients were identified retrospectively from the Danish HIV cohort.