Publications by authors named "Michael Beaupre"
The interleukin (IL)-22 cytokine can be protective or inflammatory in the intestine. It is unclear if IL-22 receptor (IL-22Ra1)-mediated protection involves a specific type of intestinal epithelial cell (IEC). By using a range of IEC type-specific Il22Ra1 conditional knockout mice and a dextran sulfate sodium (DSS) colitis model, we demonstrate that IL-22Ra1 signaling in MATH1 cells (goblet and progenitor cells) is essential for maintaining the mucosal barrier and intestinal tissue regeneration.
View Article and Find Full Text PDFThe Th17 cell-lineage-defining cytokine IL-17A contributes to host defense and inflammatory disease by coordinating multicellular immune responses. The IL-17 receptor (IL-17RA) is expressed by diverse intestinal cell types, and therapies targeting IL-17A induce adverse intestinal events, suggesting additional tissue-specific functions. Here, we used multiple conditional deletion models to identify a role for IL-17A in secretory epithelial cell differentiation in the gut.
View Article and Find Full Text PDFArticle Synopsis
- Previous research highlights the role of IL-17A in regulating gut microbiota and overall metabolic functions, but the specific site of IL-17RA signaling has not been explored.
- Using specific mouse models that lack IL-17RA in either the intestines or liver, the study found that gut IL-17RA signaling is crucial for managing metabolic functions when exposed to a high-fat diet.
- Mice lacking intestinal IL-17RA exhibited negative effects like poor glucose metabolism, abnormal hormone levels, increased body fat, and greater liver fat accumulation, linking changes in gut microbiota to systemic glucose regulation.
Article Synopsis
- IL-22 signaling plays a vital role in protecting the intestines, yet identifying the specific cell types that respond to it has been challenging due to the receptor’s expression across various cells.
- Research indicates that IL-22 signaling is linked with the differentiation of Paneth cells, important components of intestinal defense, rather than intestinal stem cells.
- The study reveals that IL-22 functions within Paneth cells to enhance their maturation, antimicrobial abilities, and interaction with gut microbiota, crucial for fighting off pathogens like Salmonella.