Publications by authors named "Michael Alexander Miles"
PLoS Negl Trop Dis
August 2014
Article Synopsis
- The research focuses on optimizing a Multilocus Sequence Typing (MLST) method for identifying genetic variations in Trypanosoma cruzi, the causative agent of Chagas disease, which is known for its significant genetic diversity.
- By analyzing thirteen concatenated gene fragments from reference strains, the study achieved a robust classification of T. cruzi into its known Discrete Typing Units (DTUs) and found that a combination of seven specific gene fragments offers the best discrimination of genetic variations.
- The proposed seven-fragment MLST scheme is suggested as a new gold standard for T. cruzi typing, providing a reliable comparison point for other typing methods, especially for simpler single locus techniques
