Publications by authors named "Michael Alexander Cowley"
Article Synopsis
- DNP, a mitochondrial uncoupling agent, influences key brain neurons (NPY and POMC) that control hunger and energy expenditure, leading to reduced food intake and increased energy use.
- DNP primarily inhibits the orexigenic (hunger-promoting) NPY neurons while activating the anorexigenic (suppressing hunger) POMC neurons through distinct ionic pathways.
- This research suggests that DNP could serve as a novel anti-obesity treatment by targeting central nervous system mechanisms, particularly in melanocortin pathways, to regulate metabolism effectively.
