Diastereoselective synthesis of (±)-trichodiene and (±)-trichodiene-D as analytical standards for the on-site quantification of trichothecenes.

The ubiquitous genus is responsible for the spoilage of vast amounts of cereals and fruits. Besides the economic damage, the danger to human and animal health by the concomitant exposure to mycotoxins represents a serious problem. A large number of species produce a variety of different mycotoxins of which the class of trichothecenes are of particular importance due to their toxicity.

First Synthesis of -Altenuene-D Suitable as Internal Standard for Isotope Dilution Mass Spectrometry.

Metabolites from fungi exhibit a variety of biological properties such as phytotoxic, cytotoxic, or antimicrobial activity. Optimization of a literature procedure culminated in an efficient total synthesis of -altenuene as well as a stable isotope-labeled derivative suitable for implementation in a LC-MS/MS method for mycotoxin analysis.