Publications by authors named "Michael A Massey"
Article Synopsis
- Concentrative nucleoside transporters (CNTs), specifically CNT1, play a crucial role in the renal reabsorption of nucleosides, but their in vivo functions were not well understood before this study.
- Researchers created CNT1 knockout (KO) mice and found that these mice had increased levels of urinary excretion of certain nucleosides and a disrupted metabolism of purine nucleosides.
- The study also revealed that CNT1 KO mice showed poor tumor control when treated with the nucleoside analog gemcitabine, but increasing the dosage to levels seen in normal mice improved its anticancer effects, highlighting the importance of CNT1 in the efficacy of nucleoside-based therapies.
