Publications by authors named "Michael A Garrett"
Article Synopsis
- Engineered living materials (ELMs) utilize living components that can grow, repair, and respond to stimuli, with E. coli as a key element due to its genetic engineering capabilities and rapid growth rates.
- A new genetic circuit was created to regulate E. coli pigmentation based on temperature, allowing these bacteria to adapt their growth strategies; they enhance pigmentation below 36 °C to boost temperature and growth rates, while decreasing pigmentation above this threshold to protect against heat stress.
- This innovation aims to improve the efficiency of ELMs by optimizing the performance of E. coli for better growth and protein production under varying seasonal temperatures.
Article Synopsis
- Temperature is an important factor for controlling gene expression in engineered cells, with most studies focusing on heat-induced methods.
- Research introduces temperature-sensitive transcriptional activators, specifically mutant forms of the Lambda phage repressor CI, which can activate gene expression through cooling at specified temperatures.
- The study demonstrates that these activators can function as both repressors and activators within the same genetic system, enhancing the ability to manipulate cellular functions with temperature variations.
Active galaxies are characterized by prominent emission from their nuclei. In the 'unified' view of active galaxies, the accretion of material onto a massive compact object--now generally believed to be a black hole--provides the fundamental power source. Obscuring material along the line of sight can account for the observed differences in the nuclear emission, which determine the classification of AGN (for example, as Seyfert 1 or Seyfert 2 galaxies).
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