Developmental trajectory and sex differences in auditory processing in a PTEN-deletion model of autism spectrum disorders.

Autism Spectrum Disorders (ASD) encompass a wide array of debilitating symptoms, including severe sensory deficits and abnormal language development. Sensory deficits early in development may lead to broader symptomatology in adolescents and adults. The mechanistic links between ASD risk genes, sensory processing and language impairment are unclear.

Sex differences during development in cortical temporal processing and event related potentials in wild-type and fragile X syndrome model mice.

Background: Autism spectrum disorder (ASD) is currently diagnosed in approximately 1 in 44 children in the United States, based on a wide array of symptoms, including sensory dysfunction and abnormal language development. Boys are diagnosed ~ 3.8 times more frequently than girls.

Developmental delays in cortical auditory temporal processing in a mouse model of Fragile X syndrome.

Background: Autism spectrum disorders (ASD) encompass a wide array of debilitating symptoms, including sensory dysfunction and delayed language development. Auditory temporal processing is crucial for speech perception and language development. Abnormal development of temporal processing may account for the language impairments associated with ASD.

Alcohol and lactation: Developmental deficits in a mouse model.

It is well documented that prenatal ethanol exposure maternal consumption of alcohol during pregnancy alters brain and behavioral development in offspring. Thus, the Centers for Disease Control (CDC) advises against maternal alcohol consumption during pregnancy. However, little emphasis has been placed on educating new parents about alcohol consumption while breastfeeding.

Transgenerational Effects of Prenatal Ethanol Exposure in Prepubescent Mice.

Fetal alcohol spectrum disorders (FASD) represent a leading cause of non-genetic neuropathologies. Recent preclinical evidence from suggests that prenatal ethanol exposure (PrEE), like other environmental exposures, may have a significant, transgenerational impact on the offspring of directly exposed animals, including altered neocortical development at birth and behavior in peri-pubescent mice. How these adverse behavioral outcomes are manifested within the brain at the time of behavioral disruption remains unknown.

Probative value of absolute and relative judgments in eyewitness identification.

It is well-accepted that eyewitness identification decisions based on relative judgments are less accurate than identification decisions based on absolute judgments. However, the theoretical foundation for this view has not been established. In this study relative and absolute judgments were compared through simulations of the WITNESS model (Clark, Appl Cogn Psychol 17:629-654, 2003) to address the question: Do suspect identifications based on absolute judgments have higher probative value than suspect identifications based on relative judgments? Simulations of the WITNESS model showed a consistent advantage for absolute judgments over relative judgments for suspect-matched lineups.

Rule-based extrapolation: a continuing challenge for exemplar models.

Erickson and Kruschke (1998, 2002) demonstrated that in rule-plus-exception categorization, people generalize category knowledge by extrapolating in a rule-like fashion, even when they are presented with a novel stimulus that is most similar to a known exception. Although exemplar models have been found to be deficient in explaining rule-based extrapolation, Rodrigues and Murre (2007) offered a variation of an exemplar model that was better able to account for such performance. Here, we present the results of a new rule-plus-exception experiment that yields rule-like extrapolation similar to that of previous experiments, and yet the data are not accounted for by Rodrigues and Murre's augmented exemplar model.

Detection of PhIP in grilled chicken entrées at popular chain restaurants throughout California.

Heterocyclic amines (HCAs), compounds formed when meat is cooked at high temperatures particularly through pan frying, grilling, or barbequing, pose a potential carcinogenic risk to the public. It is unclear whether there is any level at which consumption of HCAs can be considered safe. Efforts to measure these compounds mainly include cooking studies under laboratory conditions and some measurement of home-cooked foods, but analysis of commercially cooked foods has been minimal.

Executive attention and task switching in category learning: evidence for stimulus-dependent representation.

One class of multiple-system models of category learning posits that within a single category-learning task people can learn to utilize different systems with different category representations to classify different stimuli. This is referred to as stimulus-dependent representation (SDR). The use of SDR implies that learners switch from subtask to subtask as trials demand.

Perceptual match effects in direct tests of memory: the role of contextual fan.

The aim of the present study was to determine whether physical attributes of a memory representation would affect explicit memory performance and, if so, what type of factors would affect the size of a perceptual match effect. Subjects studied words in different, uncommon fonts and were later asked whether the word had been studied earlier. Words could be re-presented in the original font, a font studied with another word, or a font not seen earlier.

Rule-based extrapolation in perceptual categorization.

Erickson and Kruschke (1998) provided a demonstration that in certain situations people will classify novel stimuli according to an extrapolated rule, even when the most similar training exemplar is an exception to the rule. This result challenged exemplar models. Nosofsky and Johansen (2000) have called this finding into question by offering an exemplar-based explanation for those data based on the perceptual features of the stimuli.

A reexamination of stimulus-frequency effects in recognition: two mirrors for low- and high-frequency pseudowords.

The word-frequency mirror effect (more hits and fewer false alarms for low-frequency than for high-frequency words) has intrigued memory researchers, and multiple accounts have been offered to explain the result. In this study, participants were differentially familiarized to various pseudowords in a familiarization phase that spanned multiple weeks. Recognition tests given during the first week of familiarization replicated a result of W.