Publications by authors named "Micha Levy"
Objective: The aim of the present study was to evaluate a computerised monitoring system (CMS) based on laboratory test results for the detection of adverse drug reactions (ADRs) on a paediatric ward.
Methods: A prospective, 6-month pharmacoepidemiological survey was performed on a 22-bed paediatric isolation ward. ADRs were identified by intensive chart review.
Agranulocytosis and aplastic anemia are both rare, life-threatening blood dyscrasias. Agranulocytosis is mainly caused by medicines, whereas the etiology of aplastic anemia is largely unexplained. In two epidemiologic studies using the same methods, we observed a striking inverse relationship between the incidence of the two diseases in different regions, including five countries in Europe, and Israel and Thailand.
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- The study investigated the effects of colchicine and hydroxychloroquine on cyclo-oxygenases (COX) activity.
- Measurements were taken using whole blood assays and immunoassays for thromboxane (TXA) and prostaglandin 2 (PGE2).
- Results showed colchicine had no inhibitory effect on COX, while hydroxychloroquine showed mild inhibition at high concentrations, whereas standard COX inhibitors (like celecoxib) were effective.
Objective: Adverse drug reactions (ADRs) are a well-known cause of hospital admission. Nevertheless a quantitative estimate of the preventability of and physicians' awareness of these reactions is lacking.
Study Design And Methods: Using intensive bedside and computer-assisted drug surveillance methods a 13-month prospective pharmacoepidemiological survey was carried out on patients admitted to two medical wards of the Erlangen-Nuremberg University Hospital in Erlangen, Germany.