Hypopigmentation disorders pose significant diagnostic challenges in dermatology, sometimes reflecting underlying hematological conditions. This review explores the clinical presentations related to hypopigmentation in hematological disorders, focusing on vitiligo, morphea, and syndromic albinism. Vitiligo, an autoimmune disorder targeting melanocytes, involves interactions between genetic polymorphisms and immune responses, particularly regarding CD8+ T cells and IFN-γ.
View Article and Find Full Text PDFChemical vapor deposition (CVD) offers a large-area, scalable, and conformal growth of perovskite thin films without the use of solvents. Low-dimensional organic-inorganic halide perovskites, with alternating layers of organic spacer groups and inorganic perovskite layers, are promising for enhancing the stability of optoelectronic devices. Moreover, their multiple quantum-well structures provide a powerful platform for tuning excitonic physics.
View Article and Find Full Text PDFThe introduction of monoclonal antibodies such as rituximab to the treatment of cancer has greatly advanced the treatment scenario in onco-hematology. However, the response to these agents may be limited by insufficient efficacy or resistance. Antibody-drug conjugates are an attractive strategy to deliver payloads of toxicity or radiation with high selectivity toward malignant targets and limited unwanted effects.
View Article and Find Full Text PDFTuning interactions between Dirac states in graphene has attracted enormous interest because it can modify the electronic spectrum of the 2D material, enhance electron correlations, and give rise to novel condensed-matter phases such as superconductors, Mott insulators, Wigner crystals, and quantum anomalous Hall insulators. Previous works predominantly focus on the flat band dispersion of coupled Dirac states from different twisted graphene layers. In this work, a new route to realizing flat band physics in monolayer graphene under a periodic modulation from substrates is proposed.
View Article and Find Full Text PDFWhile the discovery of two-dimensional (2D) magnets opens the door for fundamental physics and next-generation spintronics, it is technically challenging to achieve the room-temperature ferromagnetic (FM) order in a way compatible with potential device applications. Here, we report the growth and properties of single- and few-layer CrTe, a van der Waals (vdW) material, on bilayer graphene by molecular beam epitaxy (MBE). Intrinsic ferromagnetism with a Curie temperature (T) up to 300 K, an atomic magnetic moment of ~0.
View Article and Find Full Text PDFPrimary cutaneous anaplastic large cell lymphoma (PCALCL) is a rare CD30 lymphoproliferative disorder characterized by the development of lesions ranging from papules to large tumors. Most cases present as localized disease, however multifocal and generalized involvement of the skin can occur. Several treatments have been proposed for PCALCL; however a highly effective standard approach to multifocal disease has not yet been elucidated.
View Article and Find Full Text PDFObjectives: to build an equity profile for assessing the impact of socioeconomic inequalities on the determinants and health outcome in Sicily (Southern Italy).
Design: descriptive study aimed to define an equity profile in Sicily by using a rich list of indicators of structure of the resident population and of distribution of determinants and health outcome, derived from the integration of available information and scientific evidence at regional level with high local detail.
Setting And Participants: the equity profile collects available information on the health status of the population in Sicily, on the determinants, and on the use of health and social services.
Objective: To report the authors' initial experience of transcarotid transcatheter aortic valve replacement (TAVR) managed with ultrasound-guided intermediate cervical plexus block.
Design: A single-center prospective study.
Setting: A teaching hospital in Paris, France.
Epitaxial graphene on SiC provides both an excellent source of high-quality graphene as well as an architecture to support its application. Although single-layer graphene on Si-face SiC has garnered extensive interest, many-layer graphene produced on C-face SiC could be significantly more robust for enabling applications. Little is known, however, about the structural properties related to the growth evolution at the buried interface for thick many-layer graphene.
View Article and Find Full Text PDFIn transcultural consultations, clinical psychologists meet families who do not share their same language, nor the same cultural reference system. This activates in them countless countertransference materials qualified as archaic. The position of co-therapist, in a group session, helps to bring together this content and present it in a secondary form to feed the patient's therapeutic process.
View Article and Find Full Text PDFRenal Diseases represent almost 6% of all Rare Diseases but are often misdiagnosed. In a survey made in Sicily in 2016, based on cases reported from all public hospitals according to a list of rare kidney diseases, we were able to collect 337 cases (199 males and 138 females). The highest prevalence was detected in children: 13.
View Article and Find Full Text PDFObjectives: to describe the prevalence of breastfeeding in Sicily Region (Southern Italy) and to analyze the socioeconomic status and other major risk factors on the attitudes towards exclusive breastfeeding.
Design: information on the practice of breastfeeding in Sicily have been collected from a Regional survey on Sudden Infant Death Syndrome (SIDS). An index of socioeconomic position was created by using data from the 2011 Census of the Italian National Institute of Statistics.
Although metal-catalysts are commonly used to create nanoscale materials at surfaces, little is quantitatively known or understood about the depth distribution profile of the catalyst during the growth process. Using X-ray reflectivity, we report the first quantitative investigation, with nanoscale resolution, of the Ag metal-catalyst depth distribution profile during metal-assisted chemical etch (MACE) growth of Si nanowire (SiNW) arrays on Si(100). Given the very low optical reflectivity of these nanowire arrays, specular reflection from these materials in the X-ray region is extremely challenging to measure because it probes interfaces on the nanoscale.
View Article and Find Full Text PDFProducing a usable semiconducting form of graphene has plagued the development of graphene electronics for nearly two decades. Now that new preparation methods have become available, graphene's intrinsic properties can be measured and the search for semiconducting graphene has begun to produce results. This is the case of the first graphene "buffer" layer grown on SiC(0001) presented in this work.
View Article and Find Full Text PDFWe show that the buried interface between a metallic nanocrystal and its supporting substrate is essential for understanding the stability of the ubiquitous class of nanomaterials that grow on a wetting layer in the Stranski-Krastanov growth mode. Importantly, these new results reveal the broad role played by quantum confinement effects in the growth of thin nanoscale metals. In situ x-ray scattering experiments on Ag/Si(111)-(7×7), where the apparent minimum stable thickness of the first two atomic layers on top of the wetting layer has posed a long-standing puzzle, show that the commensurate wetting layer is locally removed by the formation of incommensurate nanoislands, which is unanticipated for the conventional Stranski-Krastanov growth mode.
View Article and Find Full Text PDFWe report on the study of insulator-to-metal transition in post-perovskite compound CaIrO3. It is discovered that a gradual chemical substitution of calcium by yttrium leads to the onset of strong metallic behavior in this compound. This observation is in stark contrast to BaIrO3, which preserves its Mott insulating behavior despite excess of the charge carriers due to yttrium doping.
View Article and Find Full Text PDFAS MORPHOLOGY PLAYS A RELEVANT ROLE IN SOLID/SOLID CATALYSIS, WHERE THE NUMBER OF CONTACT POINTS IS A CRITICAL FEATURE IN THIS KIND OF REACTION, THREE DIFFERENT CERIA MORPHOLOGIES HAVE BEEN INVESTIGATED IN THIS WORK AS SOOT OXIDATION CATALYSTS: ceria nanofibers, which can become organized as a catalytic network inside diesel particulate filter channels and thus trap soot particles at several contact points but have a very low specific surface area (4 m(2)/g); solution combustion synthesis ceria, which has an uncontrolled morphology but a specific surface area of 31 m(2)/g; and three-dimensional self-assembled (SA) ceria stars, which have both high specific surface area (105 m(2)/g) and a high availability of contact points. A high microporous volume of 0.03 cm(3)/g and a finer crystallite size compared to the other morphologies suggested that self-assembled stars could improve their redox cycling capability and their soot oxidation properties.
View Article and Find Full Text PDFWe evaluate the factors predictive of prognosis in 91 Caucasian patients affected by ocular myasthenia gravis (OMG), followed at our Institution during an observational time, ranging from 12 to 240 months. The Myasthenia Gravis Foundation of America (MGFA) clinical classification was used to grade the disease severity. We considered as outcome measures the variation in two subscores, ocular (O-QMG) and nonocular (NO-QMG); the last one reflected bulbar, neck, extremity functions.
View Article and Find Full Text PDFIn the confectionery industry in addition to traditional and usual risks to every productive activity there are particular risks related with the use of aromas, arabic gum and other chemicals that can cause in workers exposed diseases affecting the skin and the respiratory system. Even if the literature does not show significant casuistry, but only anecdotal, risks control related to the substances above mentioned is essential, through a careful medical surveillance and a constant activity of information and training on work phases at risk outlined above together with the content of the health protocol.
View Article and Find Full Text PDFObjective: To examine the influence of addiction risk (substance abuse history [SAH]) and pain relief (PR) on nursing and non-nursing students' perceptions of pain in a postoperative vignette patient.
Methods: Using a 2 x 2 design, the independent variables SAH (present/+, absent/-) and PR (adequate, little) were varied systematically to produce four vignettes. Participants were randomly assigned to receive one of the four vignettes that described a 45-year-old man after a total hip replacement.
Objective: The aim of this study was to compare the pharmacodynamics of a new multilayer-release (MLR) formulation methylphenidate (MPH; Biphentin) with immediate-release (IR) MPH (Ritalin) in a double-blind, cross-over, placebo-controlled study in patients with attention-deficit/hyperactivity disorder (ADHD).
Method: Patients were randomized to equivalent doses of MPH as MLR (once per day), IR (twice per day) or placebo. Each treatment was taken for 1 week prior to repeated behavioral and cognitive laboratory evaluations on a single day in each phase of the crossover.