Synopsis of recent research by authors named "Micah R Rogel"
- Micah R Rogel's research predominantly focuses on the role of intermediate filament proteins, namely vimentin and laminins, in lung injury and fibrotic diseases, exploring their mechanisms and effects on inflammation and tissue remodeling.
- His studies show that vimentin is critical for the activation of the NLRP3 inflammasome and is required for effective wound repair and remodeling in alveolar epithelial cells post-injury, indicating its potential as a therapeutic target.
- Rogel also investigates the specific contributions of laminins to pulmonary fibrosis, revealing that loss of α3 laminin exacerbates bleomycin-induced fibrosis in murine models, suggesting a pivotal role in maintaining lung tissue integrity.
