Venous thrombosis and procoagulant factors in high-risk neuroblastoma.

Aim: The mechanism of increased thrombin production has been investigated in children with high-risk neuroblastoma (NB), to detect any possible association between catheter- related venous thrombosis (VT) and prothrombotic factors.

Methods: Consecutive children with high-risk NB were studied by color-doppler ultrasonography of the upper vein system and thrombophilia factors assessment. Plasma levels of Tissue Factor (TF), Vascular Endothelial Growth Factor (VEGF), Prothrombin Activation Fragment 1+2, and Thrombin-Antithrombin Complex were evaluated.

Congenital stage 1 neuroblastoma evolved into stage 4s.

A newborn with a prenatally detected adrenal mass underwent complete resection of a stage 1 favorable histology neuroblastoma (NB) without MYC-N amplification. Two months later, the infant presented with a local recurrence and multiple hepatic metastases. Close follow-up without therapy was adopted for stage 4s NB.

Venous thrombosis in children with solid tumors.

Background: The prevalence of venous thrombosis (VT) in children with solid tumor and the role of different risk factors are not defined yet.

Aim: A cross-sectional observational study was conducted to evaluate the prevalence of both symptomatic and asymptomatic catheter-associated thrombosis events in children affected with different solid tumors.

Methods: Patients with a solid tumor, admitted as day-care, were consecutively enrolled over a period of 10 months.