Publications by authors named "Micaela Compagnoni"
Article Synopsis
- Laryngeal preservation strategies in LA-LHSCC focus on curing the disease while keeping the larynx functional, reducing the need for total laryngectomy and its negative effects on quality of life.* -
- Various non-surgical treatments like radiotherapy and chemoradiation have been explored, but reliable predictors for treatment success are still lacking, which poses a significant clinical challenge.* -
- The PRESERVE trial aims to address this issue by analyzing past data to create a predictive classifier that combines various patient data types, ultimately improving patient selection for laryngeal preservation treatments.*
Autophagy is important for the removal, degradation and recycling of damaged organelles, proteins, and lipids through the degradative action of lysosomes. In addition to its catabolic function, autophagy is important in cancer and viral-mediated tumorigenesis, including Human Papillomavirus (HPV) positive cancers. HPV infection is a major risk factor in a subset of head and neck cancer (HNC), for which no targeted therapies are currently available.
View Article and Find Full Text PDFFunctional loss of E-cadherin is frequent during tumor progression and occurs through a variety of mechanisms, including proteolytic cleavage. E-cadherin downregulation leads to the conversion of a more malignant phenotype promoting Epithelial to Mesenchymal Transition (EMT). The UBC9/SUMO pathway has been also shown to be involved in the regulation of EMT in different cancers.
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